IMPACT OF ALPHA-BLOCKERS ON THE DEVELOPMENT OF BPH COMPLICATIONS
Objective: Determining the role of alpha-blockers in preventing BPH-related complications.
Study Design: a prospective study analyzing 703 patients between 1998 and 2002. 175 patients took a 1-year course of alpha-blockers, and 528 did not take any form of treatment during this year (watchful waiting). The rate of each complication (gross hematuria, acute renal failure, acute urinary retention, and prostatitis) as well as the overall complication rate were calculated for each group and compared.
Results: A 1-year course of alpha-blockers did not decrease complications associated with BPH compared to the watchful waiting group. Moreover, both watchful waiting and alpha-blockers alone are associated with considerable rate of disease progression (31.25% and 22.85% respectively).
Conclusion: alpha-blockers didn’t prevent the development of BPH related complications after 1 year of treatment. So they are not suitable to be used as a long-term treatment for BPH.