Comité de Transplantation et d'Insuffisance Rénale Chronique

A national study of kidney graft tumor treatments: Toward ablative therapy
2018
- Article
- Réf : Surgery, July 2016, 160, 1, 237-244

Background. Results of the conservative treatment of renal cell carcinomas arising in functional renal transplants are unknown compared to transplant nephrectomy. Only small series or case reports have been reported.

Methods. Data were collected from 32 transplantation centers nationwide on cases of de novo tumors in functional renal transplants presumed to be malignant between January 1988 and December 2013.

Background. Results of the conservative treatment of renal cell carcinomas arising in functional renal transplants are unknown compared to transplant nephrectomy. Only small series or case reports have been reported.

Methods. Data were collected from 32 transplantation centers nationwide on cases of de novo tumors in functional renal transplants presumed to be malignant between January 1988 and December 2013.

Results. Among 116 de novo transplant tumors, 62 were treated conservatively including: 48 by partial nephrectomy (PN) and 14 by thermal ablation (TA). These patients were compared to 30 other patients who were treated by transplant nephrectomy. The median age of the transplanted kidneys at the time of diagnosis was 43.5 years old as calculated from the donor’s age. Tumors treated by transplant nephrectomy presented more often with symptoms (pain, fever, impaired condition, hematuria) than tumors treated conservatively (P = .019). After PN, final histology showed 27 (47.5%) papillary carcinomas, 19 (32.2%) clear cell carcinomas, 1 mixed carcinoma, and 2 oncocytomas. The median tumor size treated by PN was 24 mm with no difference in comparison to the TA group. Nine patients treated by PN had postoperative complications (21%), including 4 requiring operative intervention (Clavien IIIb). None of the patients treated by TA had complications. Specific survival was 100% at the time of last follow-up (median time after treatment 37 months) for patients treated by PN or TA.

Conclusion. PN proved to be efficient in the treatment of small tumors of transplanted kidneys with good long-term functional and oncologic outcomes, including avoiding return to dialysis. TA seems to be an alternative therapy with good results in selected patients. (Surgery 2016;160:237-44.)

http://dx.doi.org/10.1016/j.surg.2016.01.022

Nephron Sparing Surgery for De Novo Kidney Graft Tumor: Results From a Multicenter National Study
Nephron Sparing Surgery for De Novo Kidney Graft Tumor: Results From a Multicenter National Study
2018
- Article
- Réf : American Journal of Transplantation 2014; XX: 1–6

Nephron sparing surgery (NSS) results in the transplanted population remain unknown because they are only presented in small series or case reports. Our objective was to study renal sparing surgery for kidney graft renal cell carcinomas (RCC) in amulticenter cohort. Data were collected from 32 French transplantation centers. Cases of renal graft de novo tumors treated as RCC since the beginning of their transplantation activity were included. Seventy-nine allograft kidney de novo tumors were diagnosed. Forty-three patients (54.4%) underwent renal sparing surgery.

Management of renal transplant urolithiasis: a multicentre study by the French Urology Association Transplantation Committee
2018
- Article
- Réf : World J Urol (2018) 36:105–109

Purpose Urolithiasis is rare among renal transplant recipients and its management has not been clearly defined.

Methods This multicentre retrospective study was organised by the Comité de Transplantation de l’Association Française d’Urologie (French Urology Association transplantation committee). Statistical analysis was performed with SPSS 19 software.

Mots clés:
Transplantation rénale / Lithiase urinaire
Mots-clés:
Renal transplant · Urolithiasis
Complications urologiques de la transplantation rénale
2014
- Réf : Prog Urol, 2014, 24, 12, 723-732


Mots clés:
Transplantation rénale / Obstruction urétérale / Fistule urinaire / Complications postopératoires
De Novo Kidney Graft Tumors: Results From a Multicentric Retrospective National Study
2014
- Réf : Am J Transplant, 2012, 3308
Renal cell carcinoma (RCC) arising in native kidneys of dialyzed and transplant patients: are they different entities?
2012
- Réf : Br J Urol, 2012, 1
Prostate cancer in renal transplant recipients
2012
- Réf : Nephrol Dial Transplant, 2008, 2374
Morbidity of retropubic radical prostatectomy for prostate cancer in renal transplant recipients: multicenter study from Renal Transplantation Committee of French Urological Association.
2012
- Réf : Urology, 2008, 1366
Early experience with sildenafil for the treatment of erectile dysfunction in renal transplant recipients
2012
- Réf : Nephrol Dial Transplant, 2003, 411
Renal Cell Carcinoma (RCC) in Patients With End-Stage Renal Disease Exhibits Many Favourable Clinical, Pathologic, and Outcome Features Compared With RCC in the General Population
2012
- Réf : Eur Urol, 2011, 366
Transplantation rénale et receveurs obèses : revue du comité de transplantation de l’Association française d’urologie
2011
- Réf : Prog Urol, 2012, 22, 12, 678-687


Mots clés:
Obésité / Index de masse corporelle / Transplantation rénale / Survie / Survie du transplant
Immunosuppression en transplantation rénale
2011
- Réf : Prog Urol, 2011, 21, 4, 250-253


Mots clés:
Transplantation rénale / Immunosuppression
Étude qualitative de l’organisation de l’activité de prélèvement et de transplantation rénale dans les services d’Urologie en France en 2010
2011
- Réf : Comité de transplantation, 2010, 1
Inhibiteurs de mTOR : de la transplantation à l'oncologie (Revue de la littérature du Comité de Transplantation - AFU 2006)
2007
- Réf : Prog Urol, 2007, 928

En 1975, dans le cadre d'un programme de recherche de nouveaux antibiotiques des laboratoires pharmaceutiques Ayerst, Venisa a isolé à partir de streptomyces hygroscopicus, une bactérie tellurique de l'Ile de Paques, une molécule de la famille des lactones macrocyclique possédant une activité antibiotique. Le nom polynésien de l'Ile de Pâques étant Rapa Nui, ils nommèrent leur découverte rapamycine. Les propriétés antibiotiques de la rapamycine étaient en fait modeste in vitro, hormis une activité antifongique sur le candida albicans.

Mots clés:
immunologie / Cancer / Transplantation / inhibiteur de mTOR.
Enquête nationale prospective sur la qualité chirurgicale des greffons rénaux en France. Etude du Comité de Transplantation de l'Association Française d'Urologie
2007
- Réf : Prog Urol, 2007, 54

En 2000, 1066 donneurs en état de mort cérébral ont été prélevés en France, permettant de réaliser 1924 transplantations rénales à partir de reins cadavériques, dont 101 à partir de donneurs vivants. En 2004, cette activité était pour la première fois en hausse de près de 16%, avec un taux de prélèvement proche de 21 par million d'habitants. Il en résultait 1290 prélèvements multi-organes (PMO) permettant de réaliser 2421 transplantations rénales, dont 164 à partir de donneurs vivants [1].

Mots clés:
Transplantation / traumatisme / Rein / artère / veine