Chemotherapy is an effective treatment in urologic cancers either for localized tumor or metastatic disease. In urologic cancers, chemotherapy always takes part in a multidisciplinary strategy including surgery, oncology and radiotherapy. Except for metastatic testicular germ cell cancers, chemotherapy is a palliative treatment in other metastatic urologic cancers such as bladder and castration-resistant prostate carcinomas. In metastatic clear cell renal carcinomas, it has not any indication and anti-angiogenic drugs are the only therapeutic options. Neoadjuvant chemotherapy in non-metastatic muscle-invasive bladder cancers must be considered as a standard treatment in fit patients.